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SARS-CoV-2 has infected more than 600 million people worldwide over the last 2.5 years. So far, there efficacy of many antiviral drugs against COVID-19 has been evaluated only in small studies conducted in different countries. Objective. To assess the efficacy of umifenovir in patients with COVID-19. Materials and methods. We performed systematic search of publications in the PubMed and Google Scholar databases. Sixteen studies with a total of 1,843 patients were included in the analysis. The following endpoints were evaluated: frequencies of negative PCR test on days 7 and 14;mortality in patients with mild, moderate, and severe disease;and frequency of fever resolution on day 7. Results. We found that patients receiving umifenovir demonstrated a significantly higher frequency of negative PCR test on day 7 than patients who received no causal therapy or other antiviral drugs (odds ratio (OR) 1.69, 95% confidence interval (CI): 1.09-2.62, p = 0.02, I2 = 13%). This difference was even more significant among patients with mild to moderate COVID-19 (OR: 2.03, 95% CI: 1.24-3.32, p = 0.005, I2 = 0%), as well as on day 14 (OR: 2.02, 95% CI: 1.35-3.94, p = 0.0007, I2 = 50%). We also observed a reduced risk of death in the studies that included only patients with mild and moderate disease (JR: 0.53, 95% CI: 0.33-0.83, p = 0.006, I2 = 0). Umifenovir therapy did not affect the frequency of fever resolution by day 7 (OR: 0.87, 95% CI: 0.49-1.56, p = 0.64, I2 = 0%). Conclusion. Umifenovir significantly accelerated virus elimination by days 7 and 14 among patients with mild to moderate COVID-19. Umifenovir also reduced the risk of death compared to other antiviral drugs.Copyright © 2022, Dynasty Publishing House. All rights reserved.
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In the industrial era 4.0, it has surpassed increasingly complex technological advances in the information system that required a very high infrastructure and facilities and prevented fraud. Counterfeiting is a procedure following an entity, statistics, or documents (observe forged documents) with plans to deceive. Falsification of extensive information certificates is exacerbated by the current economic situation in Indonesia, which is currently occurring due to the widespread epidemic, namely COVID-19. The spread of the COVID-19 outbreak has had a significant impact and changes in all sectors, especially certificate forgery in Indonesia. The imitation of busy certificates is the main focus of this journal, focusing on journal publications combined with Blockchain technology. The sophistication of blockchain technology as authentication is comparing two or more items or additional tests to ensure the accuracy, correctness, or correctness of the information. This method uses qualitative methods with data sources based on case studies in controlled supervision with the basic concept of cryptography as the basis of analysis. From the decisions made, it is hoped that this will minimize the level of forgery of certificates widely measured during the COVID-19 era. © 2022 IEEE.
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Aim: The aim of this research is to analyze the pediatric COVID-19 literature published in Turkey and to guide future research. Material(s) and Method(s): Between 11.03.2010 and 11.12.2022, the Web of Science (WoS) All Databases collection was searched for publications related to COVID-19 and pediatric patients. The keywords used during this search were coronavirus-19, COVID-19, SARS-CoV-2, novel coronavirus, 2019-nCoV, pandemic, and/or pediatric, pediatric, children, child. After this search, the selected publications were scanned one by one to determine whether they were suitable for the present study. Authors, organizations, journals, document types, distribution of publications by years (months), most used keywords were obtained from the Web of Science (WoS) All Databases collection. Descriptive analyzes were made from all these obtained data. Result(s): The number of COVID-19 publications originating from Turkey in the field of pediatrics was determined as 375. 48.2% of all publications were published in 2022. These 375 publications were published in 167 different journals. In these publications, the most active author, journal and organization were Yasemin Ozsurekci, Turkish Archives of Pediatrics and University of Health Sciences, Turkey, respectively. The most commonly used keywords were ''child, patient, pandemic, SARS-CoV and vaccine. The most active document types were research articles (295 (78.6%)), editorial materials (15 (4.0%)), letters (43 (11.5%)) and review articles (22 (5.9%)). Discussion(s): We analyzed all articles about COVID-19 from Turkey in the field of pediatrics published so far in the WoS Databases collection. It is obvious that a large literature has emerged in our country on pediatric patients, although not as much as in adults. The long-term adverse effects of the pandemic on pediatric practice and especially on children will need to be evaluated in more detail in future research.Copyright © 2023, Derman Medical Publishing. All rights reserved.
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This study aimed to outline the profile of retractions of scientific articles on COVID-19 published in journals indexed in the Scopus database between 2020 and 2021. To analyze the data, we used a bibliometric technique, with the Bibliometrix package in the R-Studio software, and descriptive statistics. Twenty-nine retractions were analyzed, and we found that the most common reasons for retraction were related to ethical issues and that 68.97% of authors have previously retracted articles. We concluded that there appears to have been a change in the publication policies of journals, which resulted in an increase in scientific retractions related to COVID-19 during the study period.
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Coronavirus disease is a serious viral infection that is characterized by severe inflammation and lymphopenia. The virus attacks many organs causing acute respiratory distress and malfunctioning of the organs leading to death. Through strengthening of the innate immune system, a balanced diet plays a critical role in defense against bacterial and viral diseases. A healthy diet before, during and after an infection can lessen the severity of the symptoms and speed up the recovery of damaged cells. Due to the Mediterranean diet's high concentration of bioactive polyphenols, which have antioxidant, anti-inflammatory, and antithrombic properties, numerous studies have suggested that it is a preventative dietary strategy against many diseases including coronavirus disease. Nutrition and herbal plants play a key role to enhance the immunity of people to protect and fight against coronavirus. Diet rich in antioxidants and phytochemicals represents perfect barrier to the virus through elevation of the innate immunity of the body. In addition, gut microbiota including prebiotics, probiotics, and synbiotics were found to enhance immunity to reduce the symptoms of the disease during infection. Protein-rich foods and honey bee products reported significant role during and post-coronavirus infection. This review presents updated information from original pre-clinical and clinical researches, and review articles as well to expose the nutritive strategies including breastfeeding benefits to infants pre-infection, during, and post-infection with coronavirus.Copyright © 2023, Scientific Foundation SPIROSKI. All rights reserved.
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INTRODUCTION: To carry out a retrospective bibliometric analysis of articles, published since the beginning of the pandemic, which addressed the topic of physical exercise and COVID-19, in order to provide a reference of origin for research on the topic. EVIDENCE ACQUISITION: This is a bibliometric study, which addressed the production / dissemination, through information recorded in the PubMed database, about physical exercise and COVID-19, published since the beginning of the pandemic. EVIDENCE SYNTHESIS: 111 publications in total were retrieved from PubMed in the first round of research and 93 publications were identified after reviewing the study titles and s. Eligibility was assessed for these 93 publications throughout the text and 76 were entered after removing duplicates and irrelevant records. According to Bradford's Law, we identified 76 publications in 53 journals from seven different countries. The countries of the journals that published the most were the United States (20, 37.7%) and the United Kingdom (15, 28.3%). The journals that most published on the subject were: European Journal of Physical and Rehabilitation Medicine, Obesity, Encephale and Progress in Cardiovascular Diseases, each with 03 studies. According to Lotka's Law, the most productive authors: Lavie CJ Smith I, with 4 articles published. When evaluating the word frequencies by Zipf's Law, it was observed that 16 words had at least 10 occurrences, with the words Covid-19, Exercise and Pandemic with 80, 39 and 38 occurrences respectively. CONCLUSION(S): According to our analysis, this research provides a current scenario of how studies related to physical exercise and COVID-19 are going on in the world, serving as a reference for researchers on this topic.Copyright © 2020 EDIZIONI MINERVA MEDICA.
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Introduction: Side effects related to COVID-19 vaccination are short-lived and disappear within a few days and can affect both pregnant and nonpregnant women. Aim(s): To evaluate the bibliometric profile of the worldwide scientific production on the side effects of COVID-19 vaccine in pregnant women, in Scopus. Material(s) and Method(s): A retrospective, cross-sectional, bibliometric study that analyzed metadata published in scientific journals indexed in Scopus during 2019 and 2021. The search and download of the papers were performed on May 13, 2022, and the SciVal program was used for the measurement of the bibliometric indicators. Result(s): The Lancet Infectious Diseases and International Journal of Gynecology and Obstetrics had the highest impact with 24.8 and 14.3 citations per publication, respectively. The institutions with the highest number of papers were Harvard University and National Institutes of Health, with 13 papers, respectively. Goldfarb Ilona Telefus, Kampmann Beate, and Khalil Asma were the authors with the highest number of papers, with 3 each. Only one publication on the side effects of COVID-19 vaccine in pregnant women was identified in 2019, whereas the highest scientific output was identified in 2021, with 127, of which 67 were from Q1. Conclusion(s): In Scopus, there is an increase in the production of papers on the side effects of the vaccine against COVID-19 in pregnant women, with the United States being the country with the most institutions with the highest scientific production. However, over the years, the quartile of the journals where these studies were published decreased.Copyright © The Author(s).
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[Background] The COVID-19 pandemic hints at the importance of modernizing disease control system. To understand the scientific research strength of our country's disease control system in recent years is conducive to formulating more targeted policies or measures to promote the modernization of the disease control system. [Objective] To understand the scientific research strength and research hotspots of China's provincial-level centers for disease control and prevention (CDCs) from 2011 to 2020, and provide evidence for the development of scientific research work, discipline construction, and talent team construction in CDCs in the future. [Methods] The Science Citation Index Expanded (SCIE) and Social Science Citation Index (SSCI) of the Web of Science Core Collection were used to retrieve SCI-indexed English papers published by 31 provincial CDCs (excluding Taiwan Province, Hong Kong and Macau Special Administrative Regions) in our country from 2011 to 2020, and to screen literature with provincial CDCs as the first affiliation for bibliometric analysis and visual analysis. Bibliometric analysis included the SCI-indexed publications of different provincial CDCs (as co-affiliation and the first affiliation), the number of SCI-indexed papers published by provincial CDCs (as the first affiliation) and funding rates by years, the high-frequency authors of SCI-indexed papers published by provincial CDCs (as the first affiliation) and their distribution, and the characteristics of the journals. Visual analysis software Citespace 5.8.R1 was used to draw keyword co-occurrence maps, cluster information tables, and emergence maps to provide information on research hotspots and their evolution. [Results] From 2011 to 2020, the number of SCI-indexed papers from 31 provincial CDCs was 8 420 (including co-affiliation), of which 2 060 papers listed provincial CDCs as the first affiliation. The provincial CDCs of Zhejiang, Jiangsu, Shanghai, Beijing, Shandong, and Guangdong were the leading six institutes in terms of the total number of SCI-indexed papers contributed as co-affiliation or the first affiliation. There was a large gap in the total number of SCI-indexed papers among the provincial CDCs. The highest total number of SCI-indexed papers contributed by provincial CDCs as the first affiliation was Zhejiang CDC (448 papers), while the lowest number was Xinjiang CDC (only 1 paper). From 2011 to 2020, the total number of SCI-indexed papers contributed by the 31 provincial CDCs as the first affiliation showed an overall increasing trend. Except for 2011, which was 63.1%, the funding rates in other years exceeded 70%. In terms of high-frequency authors, 13 first authors published >=10 SCI-indexed papers: Zhang Yingxiu from Shandong CDC had the highest number of SCI-indexed papers (47), followed by Hu Yu from Zhejiang CDC. Zhejiang, Jiangsu, Beijing, Guangdong, Shanghai, and Shandong still ranked the top six of >=4 first authored-SCI papers. In terms of journal characteristics, the top 20 journals with the highest number of SCI papers published a total of 862 papers, accounting for 41.8% (862/2 060), and PLOS ONE ranked the first (188 papers). The research hotspots were mainly concentrated in the fields of infection, child health, and epidemiology. The main keywords of the first three cluster categories were related to the research fields of adolescent overweight and obesity, HIV, and vaccine immunity. The results of keyword emergence showed that research hotspots shifted from overweight, obesity, and body mass index to antibodies, vaccines/vaccination, and cohorts. [Conclusion] The past ten years have witnessed increasing numbers of SCI-indexed papers published by provincial CDCs in our country and a stubbornly high funding rate. However, the gap among the provincial CDCs is still large seeing that economically developed eastern provincial CDCs published more SCI-indexed papers. Research hotspots have gradually shifted from overweight, obesity, and body mass index to antibodies, vaccines/vaccination, and cohorts.Copyright © 022 Shanghai Municipal Center for Disease Control and Prevention. All rights reserved.
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The aim of this research is to describe the use of telemedicine applied to patients characterised by a particular state of illness, which often drives them toward a frail and chronic status, in a systematic manner. This work employed the Tranfield approach to carry out a systematic literature review (SLR), in order to provide an efficient and high-quality method for identifying and evaluating extensive studies. The methodology was pursued step by step, analysing keywords, topics, journal quality to arrive at a set of relevant open access papers that was analysed in detail. The same papers were compared to each other and then, they were categorised according to significant metrics, also evaluating technologies and methods employed. Through our systematic review we found that most of the patients involved in telemedicine programs agreed with this service model and the clinical results appeared encouraging. Findings suggested that telemedicine services were appreciated by patients, they increased the access to care and could be a better way to face emergencies and pandemics, lowering overall costs and promoting social inclusion.Copyright © 2022 Inderscience Enterprises Ltd.
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To establish a PCR detection method for Trichomonas foetus, the primers were designed and synthesized according to the 18S rRNA gene sequence of T. foetus published by GenBank. The positive recombinant plasmid pUCm-T-TF18S of T. foetus was used as the template, and the genomic DNA of Giardia felis, Coccidia +e-lis, feline parvovirus and cDNA of feline coronavirus were used as the control for PCR detection to analyze the specificity of this method. The positive T. foetus recombinant plasmid was serial to 8 different concentrations with a gap of 10 folds, and PCR was performed to analyze the sensitivity of this method. The pUCm-T-TF18S plasmids stored at -20 " for 3, 6, 9 and 12 months were detected by PCR to analyze the stability of the method. Twenty cat fecal samples were tested using this established PCR assay and compared with those of microscopic examination. The results showed that the recombinant plasmid pUCm-T- TF18S gave specific bands after PCR amplification. The sequencing results showed that the length of the product sequence was 1 264 bp, and the BLAST sequence comparison analysis showed 99.53% sequence identity, which is consistent with that of T. foetus from cats (GenBank registration number M81842.1). The PCR method for detection of T. foetus had no cross-reactivities with C. felis, G. felis, feline coronavirus and feline parvovirus;the minimum detectable template concentration is 4.52 X 105 copies/xl;The target band of T. foetus DNA can still be detected after being stored in the refrigerator at -20 " for 12 months. This method detected 16 positive samples of T. foetus nucleic acid from 20 cat fecal samples, which is more accurate and sensitive than the results from traditional microscopy (13 samples). It is suggested that the PCR method for the detection of T. foetus is highly specific, sensitive and stable, and can be used for clinical detection and epidemiological investigation of T. foetus.Copyright © 2022, National Institute of Parasitic Diseases. All rights reserved.
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Objective: This present study seeks to summarise the psychological impact of COVID-19, address the mental health outcomes during a pandemic, and conduct a meta-analysis to draw conclusions and recommend coping strategies. Methodology: We follow the Preferred Reporting Items guideline for conducting this systematic review analysis (PRISMA). Online resources like PUBMED, ProQuest" and the "Web of Science" database were assessed to assemble the relevant research. A correlation model fixed effect model was used to generate proportions with 95 % confidence intervals (CI) and model fitted weights. Cochrane Q test and I2 tests were performed for measuring heterogeneity. Egger regression asymmetry test and funnel plot were to measure the publication bias. Result(s): Total of 12 articles were included with the main parameters of depression, anxiety, and stress. Out of these 12 articles eight (66.6%), articles were cross-sectional while four (33.3%) were online surveys. Meta-analysis shows 99.4% significant heterogeneity. Eggers test shows the 0.5726 value which indicates that no publication bias was reported. Conclusion(s): The prevalence of depression and anxiety among healthcare professionals was elevated during a pandemic. Female workers especially nurses working in COVID wards show more depression than others due to the unfavourable condition of patients.Copyright © 2022, Universidade de Sao Paulo. Museu de Zoologia. All rights reserved.
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During the Covid-19 pandemic many planned activities were virtualized. The objective of the work was to characterize the research presented at the International Scientific Meeting (ECI) of northern Peru. Quantitative, cross-sectional study, which included the evaluation of the characteristics of the s of the research papers presented at the Scientific Meeting. Of 67 investigations submitted, 64 were accepted. 65.6 % belonged to private universities, 32.81 % on thematic axis of social sciences, law and education, 54.69 % had a qualitative approach;32, 85 % with the participation of more than 3 authors, women as research leaders represented 46.9 %. 73.44 % were observational studies;87.5 % prospective, 81.25 % descriptive, 89.06 % cross-sectional. The investigations belonged mostly to professors from private universities, the participation of women in research increased, the most developed thematic axis was social, legal and education sciences, the majority was by more than three authors;The methodology was mostly observational, prospective, descriptive and cross-sectional.
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COVID-19 pandemic has paused many ongoing research projects and unified researchers' attention to focus on COVID-19 related issues. Our project traces 712,294 scientists' publications related to COVID-19 for two years, from January 2020 to December 2021, in order to detect the dynamic evolution patterns of COVID-19 collaboration network over time. By studying the collaboration network of COVID-19 scientists, we observe how a new scientific community has been built in preparation for a sudden shock. The number of newcomers grows incrementally, and the connectivity of the collaboration network shifts from loose to tight promptly. Even though every scientist has an equal opportunity to start a study, collaboration disparity still exists. Following the scale-free distribution, only a few top authors are highly connected with other authors. These top authors are more likely to attract newcomers and work with each other. As the collaboration network evolves, the increase rate in the probability of attracting newcomers for authors with higher degree increases, whereas the increase rates in the probability of forming new links among authors with higher degree decreases. This highlights the interesting trend that COVID pandemic alters the research collaboration trends that star scientists are starting to collaborate more with newcomers, but less with existing collaborators, which, in certain way, reduces the collaboration disparity. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.